Protein Details: Calcium-activated chloride channel regulator 4

Protein ID

ICDB_Pro_0838

Protein Name

Calcium-activated chloride channel regulator 4

Gene Name

CLCA4; CaCC2; UNQ562/PRO1124

Organism

Homo sapiens (Human)

Length

919 amino acids

AlphaFoldDB

AF-Q14CN2-F1-model_v4.pdb

Function

May be involved in mediating calcium-activated chloride conductance.

Sequence

MGLFRGFVFLLVLCLLHQSNTSFIKLNNNGFEDIVIVIDPSVPEDEKIIEQIEDMVTTASTYLFEATEKRFFFKNVSILIPENWKENPQYKRPKHENHKHADVIVAPPTLPGRDEPYTKQFTECGEKGEYIHFTPDLLLGKKQNEYGPPGKLFVHEWAHLRWGVFDEYNEDQPFYRAKSKKIEATRCSAGISGRNRVYKCQGGSCLSRACRIDSTTKLYGKDCQFFPDKVQTEKASIMFMQSIDSVVEFCNEKTHNQEAPSLQNIKCNFRSTWEVISNSEDFKNTIPMVTPPPPPVFSLLKISQRIVCLVLDKSGSMGGKDRLNRMNQAAKHFLLQTVENGSWVGMVHFDSTATIVNKLIQIKSSDERNTLMAGLPTYPLGGTSICSGIKYAFQVIGELHSQLDGSEVLLLTDGEDNTASSCIDEVKQSGAIVHFIALGRAADEAVIEMSKITGGSHFYVSDEAQNNGLIDAFGALTSGNTDLSQKSLQLESKGLTLNSNAWMNDTVIIDSTVGKDTFFLITWNSLPPSISLWDPSGTIMENFTVDATSKMAYLSIPGTAKVGTWAYNLQAKANPETLTITVTSRAANSSVPPITVNAKMNKDVNSFPSPMIVYAEILQGYVPVLGANVTAFIESQNGHTEVLELLDNGAGADSFKNDGVYSRYFTAYTENGRYSLKVRAHGGANTARLKLRPPLNRAAYIPGWVVNGEIEANPPRPEIDEDTQTTLEDFSRTASGGAFVVSQVPSLPLPDQYPPSQITDLDATVHEDKIILTWTAPGDNFDVGKVQRYIIRISASILDLRDSFDDALQVNTTDLSPKEANSKESFAFKPENISEENATHIFIAIKSIDKSNLTSKVSNIAQVTLFIPQANPDDIDPTPTPTPTPTPDKSHNSGVNISTLVLSVIGSVVIVNFILSTTI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 155; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 159; /ligand="Zn(2+)"; /ligand_note="catalytic"; BINDING 166; /ligand="Zn(2+)"; /ligand_note="catalytic";

Disease

Autonomic Nervous System Benign Neoplasm and Cystic Fibrosis

Location

Primarily expressed in the digestive tract; mainly in colon. Detected in smaller amounts in brain; urogenital organs; testis; and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp

DOI ID

10.1016/s0014-5793(99)00891-1; 10.1101/gr.1293003; 10.1038/ng1285; 10.1038/nature04727; 10.1101/gr.2596504; 10.1007/s00439-004-1190-y; 10.1080/00016480510028519; 10.1021/pr050492k; 10.1186/1471-2164-9-69

RefSeq

NP_036260.2 [Q14CN2-1]